Spatial and temporal characteristics of land and ocean sources and sinks of carbon remain elusive. Better understanding of the anthropogenic influences on these carbon cycle dynamics is a common goal. This experiment is one of the efforts to reach a middle ground of flux estimates for regions larger than experimental plots and flux tower footprints, but smaller than continents and ocean basins. This work tests the hypothesis that including well-calibrated continuous North American continental CO₂ measurements in the observation data used in a global inversion will provide a constraint that improves inversion estimates of the source and sink regions within North America. These continuous data are collected at tall towers and flux towers. The experiment follows the TransCom 3 synthesis inversion framework, using the NASA Goddard Space Flight Center Parameterized Chemistry and Transport Model (PCTM) with Goddard Earth Observing System, version 4 (GEOS-4) meteorological data. Seasonal fluxes are estimated for a recent year for sub-regions within North America and at continent and basin scale globally. Methods of preparing the continental continuous CO₂ measurements for the inversion will be tested. Initial inversion results will be presented along with recommendations for applicability to other global regions and use of the method to evaluate additional sites for the measurement network.